Bioactive Small Molecules
Cayman Chemical ANTIBODY -Menthol 100mg
A monoterpene alcohol with antifungal activity; inhibits the growth of F. verticillioides (MIC = 1.5 mM)
Medchemexpress LLC DBCO-PEG3-acid | 2754384-59-1 | 98.4% | 508.56 | 100 MG
DBCO-PEG3-acid is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG3-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- Non-cleavable 3 unit PEG linker
- Used in antibody-drug conjugates (ADCs) synthesis
- Contains a DBCO group
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups
Medchemexpress LLC VUF11207 fumarate | 1785665-61-3 | 99.9% | 586.65 | 10 MG
VUF11207 fumarate is a CXCR7 agonist that specifically binds to CXCR7. It reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation. This product is for research use only and not intended for sale to patients.
- Acts as a CXCR7 agonist
- Binds specifically to CXCR7
- Reduces osteoclastogenesis by inhibiting ERK phosphorylation
- Reduces bone resorption
Medchemexpress LLC GN44028 | 1421448-26-1 | 99.6% | 305.33 | 100 MG
GN44028 is a potent and orally active hypoxia inducible factor (HIF)-1α inhibitor, with an IC50 of 14 nM. It inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. It can be used in the research of cancers.
- Potent and orally active HIF-1α inhibitor
- IC50 of 14 nM against HIF-1α
- Specifically inhibits hypoxia-induced HIF-1α transcriptional activity
- Does not suppress HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization
- Useful in cancer research
Medchemexpress LLC HY-17567C 100mg Medchemexpress, Heparin (sodium salt) (MW 15kDa) CAS:9041-08-1 Purity:>98%
Medchemexpress, HY-P7149 10ug CT-1 (CHO-expressed), Human CAS: Recombinant Human Cardiotrophin-1 (CHO-expressed), a member of IL-6 family of cytokines, is a key regulator of energy homeostasis and of glucose and lipid metabolism. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY CAY10717 10mg
A multi-targeted kinase inhibitor; exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM; has activity at multiple oncogenic kinases (IC50 values less than 50 nM); highly cytotoxic against a cancer cell panel that includes chemotherapy-sensitive and -resistant cell lines (EC50s = 0.4-158 nM); inhibits the growth of HUVECs (EC50 = 34 nM)
Medchemexpress LLC Thiazole bisamide (JNJ-61803534) | 1917306-14-9 | MFCD34676883 | 99.8% | 622.41 | C23H23Cl2F6N3O4S | 5 MG
JNJ-61803534 is a research compound identified as a potent, orally active RORγt inverse agonist with demonstrated anti-inflammatory activity, including inhibition of IL-17A production in human CD4+ T cells. It has been characterized with CAS 1917306-14-9, a defined molecular formula and weight, and is supplied for laboratory research use with supporting analytical data.
- Potent RORγt inverse agonist with low-nanomolar activity.
- Demonstrated inhibition of IL-17A production in human CD4+ T cells.
- Characterized by molecular formula and molecular weight for identification.
- Provided in quantified milligram-scale quantities suitable for in vitro studies.
- Intended for research use only; not for human or clinical use.
Cayman Chemical ANTIBODY GDC-0623 25mg
A potent, ATP-uncompetitive inhibitor of MEK1 (Ki = 0.13 nM in the presence of ATP); inhibits the proliferation of A375 BRAF(V600E) and HCT116 KRAS(G13D)-mutant cancer cell lines (EC50 = 7 and 42 nM, respectively); upregulates pro-apoptotic BIM
Abcam 6-Thio-GTP (aqueous solution) (Thiogtp), Vac-1-Rac signaling inhibitor, 150UL
MW 539.24 g/mol, Purity >95%. Vac-1-Rac signaling inhibitor. Azathioprine (ab143064) metabolite. 6-mercaptopurine (ab142389) derivative. Inhibits TNF-α-induced downstream signaling via JNK. Reduces c-Jun, transcription factor-2 and NF-κB activation. Shows immunosuppressant effects.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical BMS 470539hydrochlorIde 1mg
An MC1R agonist; induces cAMP accumulation in B16/F10 murine melanoma cells and in CHO cells overexpressing human MC1R (EC50s = 11.6 and 16.8 nM, respectively); inhibits LPS-induced TNF-α production in mice (ED50 = 10 μmol/kg, s.c.); reduces LPS-induced leukocyte infiltration and paw swelling in mouse models of lung inflammation and delayed-type hypersensitivity, respectively; decreases retinal damage in a mouse model of streptozotocin-induced diabetic retinopathy; increases striatal dopamine levels and decreases the number of striatal α-synuclein aggregates in a mouse model of Parkinson’s disease at 20 mg/kg
Medchemexpress LLC HY-N7495 5mg Medchemexpress, all-trans-Anhydro Retinol CAS:1224-78-8 Purity:>98%
Medchemexpress, HY-N7495 5mg all-trans-Anhydro Retinol CAS:1224-78-8 all-trans-Anhydro Retinol (Anhydrovitamin A) is a metabolite of Vitamin A. all-trans-Anhydro Retinol is used in synthetic multivitamin preparations. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Cdk9-in-30 | 748146-89-6 | 98.0% | C16H20FNO3 | 10MG
CDK9-IN-30 is a small-molecule research inhibitor of cyclin-dependent kinase 9 (CDK9) supplied as a purified compound for in vitro and preclinical studies. It has reported antiviral activity, including inhibition of HIV-1 replication, and is typically prepared in polar aprotic solvents for assay use.
- Inhibits cyclin-dependent kinase 9 in biochemical and cellular assays.
- Shows reported inhibition of HIV-1 replication in published studies.
- High purity suitable for research applications.
- Molecular formula C16H20FNO3 and molecular weight 293.33 g·mol⁻¹.
- Soluble in DMSO; prepare stock solutions in DMSO for assays.
- Packaged in small research quantities and stored refrigerated to maintain stability.
Cayman Chemical ANTIBODY 6-epI COTC 1mg
A derivative of COTC with anticancer activity; cytotoxic to A549 and H460 NSCLC cells (IC50s = 170 and 158 µM, respectively)
Medchemexpress LLC Lanraplenib | 1800046-95-0 | 98.2% | 443.50 | 1 ML
Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor, currently in development for the treatment of inflammatory diseases. It inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time. For research use only.
- Highly selective SYK inhibitor
- Orally active
- Inhibits SYK activity in platelets
- Does not prolong bleeding time
- Suitable for inflammatory disease research
TARGETMOL CHEMICALS INC NOS-IN-1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. NOS-IN-1 (2-Imino-4-methylpiperidine acetate) is a potent and orally active inhibitor of NO synthase (NOS) isoforms. NOS-IN-1 exhibits IC50s of 0.1 uM 0.2 uM and 1.1uM for human iNOS (hiNOS) hnNOS and heNOS respectively. purity: 100%